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Frederico Pittella Silva

Universidade Federal de Juiz de Fora (UFJF)

Interference RNA (RNAi) therapy in breast cancer: the use of nanoparticles

Photo of Frederico Pittella Silva

Associated Team:

  • Natália Prado da Silva – Post-doc
  • Lívia Mara Silva - PhD Student
  • Davi Trombini Aleixo - PhD Student
  • Estael Cruz Cazarim - PhD Student
  • Kezia Cristine Barbosa Ferreira - PhD Student
  • Lívia do Nascimento Grossi - PhD Student
  • Allana Carvalho Silva - PhD Student

Published Articles Related to the Network:

Other products related to the Network:

  • Development of the siRNASeeker software, partnership between Matheus Gomes (UFU) and Frederico Pittella (UFJF).
  • PhD thesis defense by Ana Beatriz Caribé dos Santos Valle (2024).
  • “Young Scientist Travel Grant 2024” Award – Ana Beatriz Caribé dos Santos Valle.

Project Photos and Illustrations:

Figura 1: Curva de distribuição de tamanho de HNP-siHOXB7
Figure 1. Size distribution curve of HNP-siHOXB7 (A) and HNP-mock (B) by intensity. Each curve in a different color represents a single measurement (n = 9).
Figura 7: Vias de silenciamento de RNAi de miRNA e siRNA
Figure 2. miRNA and siRNA RNAi silencing pathways. Created with BioRender.com
Figura 13: Representação da nanopartícula híbrida
Figure 3. Representation of the hybrid nanoparticle formed by the inorganic core composed of calcium phosphate, with complexed siRNA, and the organic coating of PEG-polyanion block copolymer. Source: Prepared by the author with BioRender (2024), adapted from Pittella et al., 2011.
Figura 14: Representação da internalização e escape endossomal
Figure 4. Representation of internalization and endosomal escape promoted by NP. Source: Prepared by the author with BioRender (2024).